Weapon PRIME was the Liefeldian re-imagining of Alpha Flight, so there's your problem right there. Furman was just following the unfortunate trend.

The earlier comments about Delphine Courtney and whether she could come back make me wonder a bit about her origin. She was an enigma that really was never properly answered. Who created her? Was it Roxxon? Conceivably there could be another copy of her somewhere.

Roxxon itself might be a good option for villains, we know they had an interest in the Guardian suit technology, maybe that's a thread that could be revived.